Intensive BP targets: safe and potentially beneficial after kidney transplant

  • Pagonas N & al.
  • Sci Rep
  • 19 Jul 2019

  • International Clinical Digest
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Takeaway

  • The new lower American Heart Association (AHA) BP targets for patients with chronic kidney disease (CKD) are safe for kidney transplant recipients (KTRs) and potentially beneficial.

Why this matters

Study design

  • German study of 815 KTRs (mean age, 50.0 years; 60.1% male) stratified by mean office SBP:
  • Funding: None disclosed.   

Key results

  • Over a median of 83.5 months, 118 patients resumed dialysis and 110 died.
  • Mean SBP
  • Benefit appeared driven by a 47% reduction in mortality risk: HR, 0.53 (P=.03).
  • Benefit of mean SBP of 130-139 mmHg vs ≥140 mmHg was not significant for composite endpoint (P=.08) or graft survival (P=.09).
  • Analysis restricted to SBP in first 12 months: lowest all-cause mortality (P<.001 and graft loss seen with sbp mmhg poorest outcomes at mmhg.>

    Limitations

    • Retrospective, cannot show causality.
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