- In men with unfavorable intermediate/high-risk localized prostate cancer (PCa) who underwent radical prostatectomy (RP) within 6 months, time between diagnosis and surgery does not affect outcomes.
Why this matters
- The effect of time between diagnosis and surgery on oncologic outcomes is unclear; some guidelines recommend RP within 1 month.
- 2303 men with Gleason grade group (GG) ≥3 PCa underwent RP within 6 months of diagnosis during 2005-2018.
- Funding: None disclosed.
- 54% had GG3, 26% had GG4, and 20% had GG5 disease.
- 72% underwent RP
- 68% men had follow-up post-RP for >1 year.
- Patients who had RP
- positive surgical margin (34% vs 32%; P=.7);
- extraprostatic extension (72% vs 74%; P=.8);
- seminal vesicle invasion (32% vs 33%; P=.8);
- lymph node involvement (19% vs 16%; P=.5);
- 5-year biochemical recurrence-free survival rate: GG3, 69% vs 66% (P=.6); GG4, 51% vs 57% (P=.4); GG5, 48% vs 54% (P=.2);
- 10-year metastasis-free survival (MFS) rates: GG3, 84% vs 91% (P=.4); GG4, 72% vs 81% (P=.8); and
- 5-year MFS rate in GG5 patients (81% vs 71%; P=.9).
- Retrospective design.