Investigational herpes zoster vaccine is safe, effective in older adults with prior infection

Access to the full content of this site is available only to registered healthcare professionals. Register to read more


  • An adjuvanted recombinant subunit herpes zoster vaccine (Hz/su) was found safe and immunogenic in adults aged ≥50 y with a prior history of herpes zoster infection documented by a physician.

Why this matters

  • The patient population, older adults with prior history of herpes zoster infection, had been excluded from prior clinical trials.

Study design

  • This was a phase 3, nonrandomized, open-label, multicenter trial of 96 older adults administered 2 doses of HZ/su 2 mo apart and followed for another 12 mo.
  • Immunogenicity was assessed by anti-glycoprotein E (gE) antibodies using ELISA.
  • The primary immunogenicity outcome was met "if the lower limit of the 95% CI of the vaccine response rate (VRR), defined as a 4-fold increase in anti-gE over baseline, at Month 3 was ≥60%."
  • Funding: GlaxoSmithKline.

Key results

  • The primary immunogenicity outcome was fulfilled, with the VRR at month 3 being 90.2%.
  • 77.9% of participants reported local solicited adverse events (AEs); 71.6% reported general solicited AEs.
  • The most common solicited AEs were pain at the injection site, fatigue, headache, myalgia, and shivering.


  • Nonrandomized, open-label design.