Investigational herpes zoster vaccine is safe, effective in older adults with prior infection

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  • An adjuvanted recombinant subunit herpes zoster vaccine (Hz/su) was found safe and immunogenic in adults aged ≥50 y with a prior history of herpes zoster infection documented by a physician.

Why this matters

  • The patient population, older adults with prior history of herpes zoster infection, had been excluded from prior clinical trials.

Study design

  • This was a phase 3, nonrandomized, open-label, multicenter trial of 96 older adults administered 2 doses of HZ/su 2 mo apart and followed for another 12 mo.
  • Immunogenicity was assessed by anti-glycoprotein E (gE) antibodies using ELISA.
  • The primary immunogenicity outcome was met "if the lower limit of the 95% CI of the vaccine response rate (VR...