Irritable bowel syndrome linked to higher osteoporosis risk

  • Wongtrakul W & al.
  • Osteoporos Int
  • 1 Feb 2020

  • curated by Sarfaroj Khan
  • UK Clinical Digest
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Takeaway

  • This meta-analysis suggests that the risk for osteoporosis is significantly higher among patients with irritable bowel syndrome (IBS).

Why this matter

  • Early intervention including weight-bearing exercise, adequate intake of vitamin D and calcium, and early screening may be helpful to prevent the development of osteoporosis.

Study design

  • Meta-analysis included 5 studies (n=526,633) after a search across MEDLINE, EMBASE and Google Scholar database.
  • Funding: None disclosed.

Key results

  • Patients with IBS were significantly at an increased risk for osteoporosis compared with those without IBS (risk ratio [RR], 1.95; 95% CI, 1.04-3.64; P=.04; I2=100%).
  • The pooled results of 3 studies demonstrated that patients with IBS vs those without were at a higher risk for osteoporotic fracture, but it was not statistically significant (OR, 1.58; 95% CI, 0.95-2.62; P=.08; I2=99%).
  • In the sensitivity analysis:
    • The pooled results of 4 cohort studies showed that the risk for osteoporosis was higher in patients with IBS vs those without (RR, 1.55; 95% CI, 1.39-1.72; I2=59%).
    • The pooled results of 4 cohort studies found a higher risk for osteoporotic fracture in patients with IBS vs those without (RR, 1.27; 95% CI, 1.20-1.39).

Limitations

  • Heterogeneity among studies.
  • Publication bias.