Takeaway
- This meta-analysis suggests that levels of cancer antigen-125 (Ca-125) are significantly higher in patients with Afib than those in sinus rhythm.
Why this matters
- Whether Ca-125 levels are higher in patients with Afib and predict the risk for Afib remains controversial.
- This finding has a significant clinical implication, as Ca-125 may be used as a novel biomarker of Afib.
Study design
- Systematic review and meta-analysis of 10 studies evaluating the association between Ca-125 levels and Afib.
- Funding: None disclosed.
Key results
- Compared with patients in sinus rhythm, Ca-125 was significantly higher in those with Afib (mean difference, 16 U/mL; P<.05).
- Pooled results showed that elevated Ca-125 levels are associated with 1.39 times higher risk of Afib (P<.05).
Limitations
- Small sample size among included studies.
- Heterogeneity among included studies.
References
References