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Clinical Summary

Is Ca-125 a predictor of Afib risk?

Takeaway

  • This meta-analysis suggests that levels of cancer antigen-125 (Ca-125) are significantly higher in patients with Afib than those in sinus rhythm.

Why this matters

  • Whether Ca-125 levels are higher in patients with Afib and predict the risk for Afib remains controversial.
  • This finding has a significant clinical implication, as Ca-125 may be used as a novel biomarker of Afib.

Study design

  • Systematic review and meta-analysis of 10 studies evaluating the association between Ca-125 levels and Afib.
  • Funding: None disclosed.

Key results

  • Compared with patients in sinus rhythm, Ca-125 was significantly higher in those with Afib (mean difference, 16 U/mL; P<.05).
  • Pooled results showed that elevated Ca-125 levels are associated with 1.39 times higher risk of Afib (P<.05).

Limitations

  • Small sample size among included studies.
  • Heterogeneity among included studies.

References


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