- In this study involving older British men, serum conjugated linoleic acid (CLA) was associated with a lower risk for heart failure (HF) despite of unfavourable effects on blood lipids.
- Association observed only in those with high dairy intake, which is a major dietary CLA source.
Why this matters
- Findings of this study have important implications on dietary interventions for preventing HF in older men at higher risk for HF.
- Further trials in different population should confirm if increasing dietary CLA could reduce HF risk.
- 3806 men (age, 60-79 years) from the British Regional Heart Study without diagnosis of HF were followed up for an average of 13 years.
- CLA measured as a percentage of total fatty acids (CLA%).
- Funding: British Heart Foundation.
- After adjusting for HF risk factors, higher CLA% was associated with significantly reduced risk for HF (aHRquartile 4 vs 1, 0.64; 95% CI, 0.43-0.96).
- Association between CLA% and reduced HF risk was seen only in those with high dairy intake (aHRquartile 4 vs 1, 0.41; 95% CI, 0.17-0.98; Pinteraction=.03).
- Higher CLA% was associated with lower high-density lipoprotein cholesterol (Ptrend<.0001 higher total cholesterol>trend<.0001 and higher systolic bp>trend=.005).
- No such association was observed for coronary heart disease.
- Study limited to older, predominantly white European males.
- Self-administered questionnaire evaluated dairy intake.