- HbA1c may not be an accurate reflection of blood glucose for the diagnosis/monitoring of diabetes in people with cirrhosis awaiting transplant as it reflects altered erythrocyte presentation.
Why this matters
- Diabetes is a leading cause of liver disease, with cirrhosis responsible for a considerable number of deaths in people with diabetes.
- HbA1c and random plasma glucose data were collected for patients with diabetes without liver disease (n=125) and for patients awaiting liver transplant with diabetes and cirrhosis (n=29).
- Funding: None disclosed.
- Median (interquartile range [IQR]) for diabetes with cirrhosis group vs for the group without cirrhosis.
- age: 55 (49-63) vs 60 (50-71) years (P=.13)
- HbA1c concentrations: 41 (32-56) mmol/mol [5.9% (5.1%-7.3%)] vs 61 (52-70) mmol/mol [7.7% (6.9%-8.6%); P<.001>
- glucose concentrations: 8.4 (7.0-11.2) mmol/L vs 7.3 (5.3-11.5) mmol/L (P=.17)
- Small sample of patients with cirrhosis and diabetes.