- Lower intelligence quotient (IQ) was found to be associated with low-grade systemic inflammation and increase in risk for schizophrenia and other non-affective psychoses (ONAP) in adulthood.
- Low-grade inflammation may influence risk for schizophrenia by affecting neurodevelopment
Why this matters
- Abnormal neurodevelopment plays a significant role in the worsening of schizophrenia.
- Not many studies have assessed the association between erythrocyte sedimentation rate (ESR) and subsequent risk for schizophrenia and related psychosis.
- Population-based cohort study of 638,213 Swedish men examined the associations of ESR with IQ (cross-sectional) and psychoses (longitudinal) between 1969 and 1983.
- Participants’ intelligence was assessed by testing the logic/general intelligence, verbal intelligence, visuospatial perception and mechanical skills in solving mathematical or physical problems.
- Funding: None disclosed.
- After adjustments, with every 1-point increase in IQ, decrease in schizophrenia (HR, 0.961; 95% CI, 0.960-0.963) and ONAP (HR, 0.973; 95% CI, 0.971-0.975) was observed.
- In patients with high ESR (7-10 mm/hour), risk for schizophrenia (aHR, 1.14; 95% CI, 1.01–1.28) was increased and risk for ONAP (aHR, 0.85; 95% CI, 0.74-0.96) was decreased.
- After adjustment, every 1-point increase in ESR increased the risk for schizophrenia (P=.070) but decreased the risk for ONAP (P=.053).
- Only male participants were included.