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Clinical Summary

Is psoriasis a risk factor for inflammatory bowel disease?

Takeaway

  • In a 20-year study, patients with psoriasis showed significantly higher risk for inflammatory bowel disease (Crohn’s disease and ulcerative colitis) vs matched individuals without psoriasis.

Why this matters

  • Patients with psoriasis should be monitored for Crohn’s disease and ulcerative colitis.
  • Treating psoriasis may delay development of inflammatory bowel disease.

Study design

  • Study of 235,038 patients with psoriasis from a 20-year nationwide Danish cohort and 235,038 matched individuals without psoriasis from the general population.
  • Co-primary endpoints: First-time diagnosis of Crohn’s disease or ulcerative colitis. 
  • Funding: None.

Key results

  • Crohn’s disease
    • 257/464/664 and 124/252/383 patients with psoriasis and individuals from general population, respectively, developed definite/probable/possible Crohn’s disease during follow-up.
    • Risk for definite/probable/possible Crohn’s disease was 88%/74%/63% higher in patients with any psoriasis vs general population (all P<.0001).
    • Risk for definite/probable/possible Crohn’s disease was 83%/70%/59% higher in patients with psoriasis without psoriatic arthritis vs general population (all P<.0001).
    • Risk for definite/probable/possible Crohn’s disease was 210%/139%/128% higher in patients with psoriasis with psoriatic arthritis vs general population (all P<.0001).
  • Ulcerative colitis
    • 504/870/1274 and 325/546/778 patients with psoriasis and individuals from the general population, respectively, developed definite/probable/possible ulcerative colitis.
    • Risk for definite/probable/possible ulcerative colitis was 49%/52%/56% higher in patients with any psoriasis vs general population (all P<.0001).
    • Risk for definite/probable/possible ulcerative colitis was 50%/51%/53% higher in patients with psoriasis without psoriatic arthritis vs general population (all P<.0001).
    • Risk for probable/possible ulcerative colitis was 81%/121% higher in patients with psoriasis with psoriatic arthritis vs general population (all P<.0001).

Limitations

  • Observational design.

References


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