- This study involving data from prospective UK Biobank cohort finds no association between use of vitamin D and/or calcium supplementation and increased risk for hospital admission or death after ischaemic or non-ischaemic cardiovascular events.
- Lack of association was robust for a range of confounders and similar for both men and women.
Why this matters
- Calcium and/or vitamin D supplementation was considered extremely safe until a study observed increased risk for myocardial infarction in older women receiving calcium supplementations.
- With calcium/vitamin D supplementation being the major therapy for improved bone health, related cardiovascular side effects need thorough investigation.
- 475,255 participants (median age, 57 years; 264,984 women; 210,271 men) with available data for calcium and vitamin D intake were evaluated.
- Funding: UK Medical Research Council.
- No association in either men or women was observed between calcium (Pwomen=.88; Pmen=.93), vitamin D (Pwomen=.51; Pmen=.63) or combined calcium/vitamin D (Pwomen=.96; Pmen=.89) supplementation and increased hospitalisation with any cardiovascular event.
- No association was observed between calcium (Pwomen=.44; Pmen=.26), vitamin D (Pwomen=.58; Pmen=.43) or combined calcium/vitamin D (Pwomen=.88; Pmen=.25) supplementation and increased death for any cardiovascular event.
- Results were consistent in unadjusted models and models adjusted for BMI, smoking, prior cardiac disease, alcohol, systolic BP and diabetes/cholesterol medications.
- Self-report assessed vitamin D and calcium supplementation.