- Italian study finds that acute kidney injury (AKI) occurs in about 10% of patients who undergo lung cancer surgery.
- Preoperative serum creatinine and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels are good predictors of AKI risk.
Why this matters
- AKI is a frequent complication after surgery, but its incidence in patients with lung cancer was understudied.
- Prospective, observational study.
- 2179 patients underwent surgery for lung cancer.
- Study was unfunded.
- 10% of patients developed AKI, with stage 1 being the most common (90%).
- Patients with AKI were more likely to be men (82% vs 59%) and have hypertension (65% vs 40%; P<.0001 for both>
- Patients with AKI had higher rates of postoperative complications, including atrial fibrillation (23% vs 9%; P<.0001 more blood transfusions vs p and respiratory failure as well a longer hospital stay days>
- Serum creatinine (area under the curve [AUC], 0.70; 95% CI, 0.67-0.74) and NT-proBNP (AUC, 0.71; 95% CI, 0.67-0.74), both alone and in combination (AUC, 0.74; 95% CI, 0.71-0.77), were independent predictors of AKI.
- Single-center study.