Italian study: AKI in 10% of lung cancer surgery cases

  • Cardinale D & al.
  • Lung Cancer
  • 1 Sep 2018

  • curated by Kelli Whitlock Burton
  • Univadis Clinical Summaries
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Takeaway

  • Italian study finds that acute kidney injury (AKI) occurs in about 10% of patients who undergo lung cancer surgery.
  • Preoperative serum creatinine and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels are good predictors of AKI risk.

Why this matters

  • AKI is a frequent complication after surgery, but its incidence in patients with lung cancer was understudied.

Study design

  • Prospective, observational study.
  • 2179 patients underwent surgery for lung cancer.
  • Study was unfunded.

Key results

  • 10% of patients developed AKI, with stage 1 being the most common (90%).
  • Patients with AKI were more likely to be men (82% vs 59%) and have hypertension (65% vs 40%; P<.0001 for both>
  • Patients with AKI had higher rates of postoperative complications, including atrial fibrillation (23% vs 9%; P<.0001 more blood transfusions vs p and respiratory failure as well a longer hospital stay days>
  • Serum creatinine (area under the curve [AUC], 0.70; 95% CI, 0.67-0.74) and NT-proBNP (AUC, 0.71; 95% CI, 0.67-0.74), both alone and in combination (AUC, 0.74; 95% CI, 0.71-0.77), were independent predictors of AKI.

Limitations

  • Single-center study.

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