IVF: potential effects of endocrine-disrupting chemicals

  • Fertil Steril

  • International Clinical Digest
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • In vitro fertilization (IVF) may be affected by exposure to endocrine-disrupting chemicals (EDCs).

Why this matters

  • EDCs are pollutants that interfere with the synthesis, function, storage, and metabolism of hormones and can affect gene expression.
  • Examples of EDCs include: pesticides, herbicides, plasticizers, and persistent organic pollutants.
  • They occur in medical supplies, paints, cosmetics, and plastics.
  • EDCs can accumulate in tissues and fluids.
  • It is not known if there are safe levels of exposure.
  • EDCs may act synergistically.

Study design

  • A "reflection," literature review, and expert commentary.
  • Funding: Author support from the IVI Foundation and Spanish Ministry of Economy and Competitiveness.

Key highlights

  • Du et al. (2019):
    • Phthalates and their metabolites were detected in follicular fluid in IVF patients. 
    • Levels were low, but associated with lower estradiol levels.
  • Hannon et al. (2015):
    • EDCs were associated with lower fertilization rates.
    • Also associated with a lower proportion of high-quality embryos relative to the number of retrieved oocytes.

Limitations

  • Brief review of literature.
  • Association is limited because of limited studies.

Please confirm your acceptance

To gain full access to GPnotebook please confirm:

By submitting here you confirm that you have accepted Terms of Use and Privacy Policy of GPnotebook.

Submit