Juvenile idiopathic arthritis linked to altered HDL functionality

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Takeaway

  • The presence of juvenile idiopathis arthritis (JIA) is associated with alterations in HDL particle distribution, cholesterol efflux and non-lipid transporting activities, which have implications for cardiovascular risk,

Study design

  • Prospective cross-sectional matched characteristic study of 44 patients, comprising 29 adolescents and young adults with JIA and 15 controls.
  • The disease group were aged 10-35 years.

Key results

  • JIA patients demonstrated lower levels of HDL cholesterol [47.0 (40.0, 56.0) vs. 56.0 (53.0, 61.0) mg/dL, P=0.04], total HDL [29.5 (27.9, 32.3) vs. 32.9 (31.6, 36.3) mg/dL, P=0.05] and large HDL [5.1 (3.7, 7.3) vs. 8.0 (6.7, 9.7) mg/dL, P=0.04] particles.
  • JIA patients demonstrated greater cholesterol efflux mediated via ATP binding cassette A1 (ABCA1) [17.3% (12.8, 19.7) vs. 10.0% (5.8, 16.0), P=0.05] and less efflux mediated via ATP binding cassette G-1 (ABCG1) [3.2% (2.0, 3.9) vs. 4.8% (3.5, 5.8), P=0.01] and SR-B1 [6.9% (6.0, 8.4) vs. 9.1% (8.6, 10.2), P=0.002] compared with controls.
  • Exposing macrophages to serum from JIA patients result...