Kidney stones tied to RCC, UTUC in Netherlands study

Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • Individuals with a history of kidney stones showed higher risk for overall renal cell carcinoma (RCC), papillary RCC (pRCC), and upper tract urothelial carcinoma (UTUC) than those without.
  • RCC risk was higher with diagnosis before age 40 years.

Why this matters

  • This is the first prospective study to assess the relationship between kidney stones and RCC and UTUC risk.

Study design

  • Prospective Netherlands Cohort study included 4352 participants who completed a self-administered questionnaire on diet, medical conditions, and other risk factors for cancer.
  • Funding: None.

Key results

  • 608 cases of RCC and 140 cases of UTUC were identified in 20.3 years.
  • Presence of kidney stones was associated with an increased overall risk for RCC (HR, 1.39; 95% CI, 1.05-1.84) vs no kidney stones.
  • Participants with kidney stones showed higher risk for papillary RCC (HR, 3.08; 95% CI, 1.55-6.11), but not clear-cell RCC (HR, 1.14; 95% CI, 0.79-1.65).
  • Participants with kidney stones had higher risk for UTUC (HR, 1.66; 95% CI, 1.03-2.68); no difference was found between the localization in the renal pelvis or the ureter (P=.841).
  • Diagnosis of kidney stones at age

Limitations

  • Questionnaire-based data.