- Individuals with a history of kidney stones showed higher risk for overall renal cell carcinoma (RCC), papillary RCC (pRCC), and upper tract urothelial carcinoma (UTUC) than those without.
- RCC risk was higher with diagnosis before age 40 years.
Why this matters
- This is the first prospective study to assess the relationship between kidney stones and RCC and UTUC risk.
- Prospective Netherlands Cohort study included 4352 participants who completed a self-administered questionnaire on diet, medical conditions, and other risk factors for cancer.
- Funding: None.
- 608 cases of RCC and 140 cases of UTUC were identified in 20.3 years.
- Presence of kidney stones was associated with an increased overall risk for RCC (HR, 1.39; 95% CI, 1.05-1.84) vs no kidney stones.
- Participants with kidney stones showed higher risk for papillary RCC (HR, 3.08; 95% CI, 1.55-6.11), but not clear-cell RCC (HR, 1.14; 95% CI, 0.79-1.65).
- Participants with kidney stones had higher risk for UTUC (HR, 1.66; 95% CI, 1.03-2.68); no difference was found between the localization in the renal pelvis or the ureter (P=.841).
- Diagnosis of kidney stones at age
- Questionnaire-based data.