Krill oil and TAG, VLDL: a pilot study | Lipids Health Dis

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  • Krill oil supplementation appears to be beneficial as it decreases cardiovascular disease risk parameters through its effects on plasma a triacylglycerol (TAGs), lipoprotein particles, fatty acid profile, redox status and possibly inflammation. 

Study Design

  • A 28 days intervention study assessing effect-parameters of dietary supplementation with krill oil (832.5 mg EPA and DHA per day) in 17 healthy volunteers (18-36 years).
  • Plasma lipids, lipoprotein particle sizes, fatty acid composition in plasma and red blood cells (RBCs), plasma cytokines, antioxidant capacity, acylcarntines, carnitine, choline, betaine, and trimethylamine-N-oxide (TMAO) were measured before and after supplementation.

Key Results

  • Plasma TAG and large very-low density lipoprotein & chylomicron particle concentrations decreased after participants took krill oil for 28 days 
  • A significant reduction in the TAG/HDL cholesterol resulted.
  • Krill oil supplementation also decreased n-6/n-3 polyunsaturated fatty acids (PUFA) ratio both in plasma and RBCs, due to the increase of EPA, DHA and docosapentaenoic acid and reduced amount of arachidonic acid (AA).
  • Krill oil intake increased the antioxidant capacity, double bond index and the fatty acid anti-inflammatory index.

Why This is Important
  • Supplementing with krill oil may help prevent the development of a number of risk factors linked to cardiovascular disease.