- Primary surgery, disease stage, and recurrence are associated with poor long-term laryngectomy-free survival in patients receiving curative treatment for laryngeal cancer.
Why this matters
- Preserving laryngeal function is an important but challenging treatment goal for patients with laryngeal cancer.
- Functional larynx preservation was 74.6%.
- 5-year laryngectomy-free survival rates were greater in patients who received radiotherapy or chemoradiotherapy (RT/CRT) compared with patients who received surgery (69% vs 57%; P<.01 vs in patients with stage iii-ivb disease>
- Patients treated with surgery had higher rates of tracheostomy (53.4% vs 29.5%; P<.01 and feeding tube use vs compared with patients treated rt>
- Primary surgery (HR, 1.84; P<.001 stage iii-ivb and tumor recurrence were associated with poor laryngectomy-free survival in multivariate analysis.>
- cT 3-4 disease (OR, 10.19; P<.001 primary surgery and tumor recurrence were associated with nonfunctional larynx at the time of last follow-up in multivariate analysis.>
- 477 patients with laryngeal cancer treated with curative intent (24.7% primary surgery, 75.3% RT/CRT) were analyzed for prognostic factors and outcomes.
- Funding: None.
- Retrospective study design.