Laryngeal cancer: 3 predictors of poor long-term functional outcome

  • Anschuetz L & al.
  • Radiat Oncol
  • 11 Jun 2019

  • curated by Brian Richardson, PhD
  • Univadis Clinical Summaries
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Takeaway

  • Primary surgery, disease stage, and recurrence are associated with poor long-term laryngectomy-free survival in patients receiving curative treatment for laryngeal cancer.

Why this matters

  • Preserving laryngeal function is an important but challenging treatment goal for patients with laryngeal cancer.

Key results

  • Functional larynx preservation was 74.6%.
  • 5-year laryngectomy-free survival rates were greater in patients who received radiotherapy or chemoradiotherapy (RT/CRT) compared with patients who received surgery (69% vs 57%; P<.01 vs in patients with stage iii-ivb disease>
  • Patients treated with surgery had higher rates of tracheostomy (53.4% vs 29.5%; P<.01 and feeding tube use vs compared with patients treated rt>
  • Primary surgery (HR, 1.84; P<.001 stage iii-ivb and tumor recurrence were associated with poor laryngectomy-free survival in multivariate analysis.>
  • cT 3-4 disease (OR, 10.19; P<.001 primary surgery and tumor recurrence were associated with nonfunctional larynx at the time of last follow-up in multivariate analysis.>

Study design

  • 477 patients with laryngeal cancer treated with curative intent (24.7% primary surgery, 75.3% RT/CRT) were analyzed for prognostic factors and outcomes.
  • Funding: None.

Limitations

  • Retrospective study design.

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