Laryngeal cancer: laser transoral microsurgery delivers excellent results

  • Djukic V & al.
  • Eur Arch Otorhinolaryngol
  • 3 May 2019

  • curated by Brian Richardson, PhD
  • Univadis Clinical Summaries
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Takeaway

  • Patients with early laryngeal cancer treated with laser transoral microsurgery had excellent survival outcomes, according to a retrospective study.

Why this matters

  • Findings support benefits of laser transoral microsurgery and elucidate the effect of common risk factors.

Key results

  • 5-year OS was 92.5%, and 5-year disease-specific survival (DSS) was 95.3%.
  • Age (HR, 1.43; P=.005), alcohol consumption (HR, 11.62; P=.022), histological tumor grade (HR, 3.453 [P=.006] for G2; HR, 4.069 [P=.004] for G3), type VI endoscopic cordectomy (HR, 6.43; P=.041), and lack of laryngeal preservation (HR, 10.04; P=.001) were associated with DSS in multivariate analysis.
  • Age (HR, 1.048; P=.043), histologic grade (HR, 2.022 [P=.001] for G2; HR, 3.541 [P=.024] for G3), stage T2 with impaired vocal fold mobility (HR, 1.045; P=.047), and lack of laryngeal preservation (HR, 3.31; P=.001) were associated with DFS in multivariate analysis.

Study design

  • 234 patients with early (T1 or T2N0M0) laryngeal squamous cell carcinoma treated with laser transoral microsurgery were analyzed for survival outcomes and associated factors.
  • Funding: Clinical Center of Serbia.

Limitations

  • Retrospective study.