Laryngeal SCC: inflammatory markers predict postresection survival in Chinese study

  • Chen L & al.
  • BMC Cancer
  • 13 Aug 2018

  • curated by Brian Richardson, PhD
  • Univadis Clinical Summaries
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Takeaway

  • Preoperative neutrophil-to-lymphocyte ratio (NLR) and postoperative monocyte-to-lymphocyte ratio (MLR) are independently associated with survival of patients with laryngeal squamous cell carcinoma (SCC) after resection.

Why this matters

  • Better understanding of prognostic markers can help guide patient management.

Key results

  • Preoperative NLR (HR, 2.53; P<.001 platelet-to-lymphocyte ratio mlr and alkaline phosphatase were associated with os in univariate analysis. style="list-style-type:circle;">
  • Preoperative NLR was associated with OS in multivariate analysis (HR, 1.64; P=.026).
  • Preoperative NLR (HR, 2.13; P<.001 and plr were associated with pfs in univariate analysis. style="list-style-type:circle;">
  • Preoperative NLR was associated with PFS in multivariate analysis (HR, 1.52; P=.029).
  • Postoperative NLR (HR, 3.18; P<.001 plr and mlr were associated with os in univariate analysis. style="list-style-type:circle;">
  • Postoperative MLR was associated with OS in multivariate analysis (HR, 2.02; P=.002).
  • Postoperative NLR (HR, 2.18; P<.001 plr and mlr were associated with pfs in univariate analysis. style="list-style-type:circle;">
  • Postoperative MLR was associated with PFS in multivariate analysis (HR, 1.57; P=.026).
  • Study design

    • 361 patients with laryngeal SCC who underwent resection were analyzed for inflammatory markers and survival.
    • Funding: None.

    Limitations

    • Retrospective, single-center study.

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