Light wine consumption tied to CVD benefit in CKD

  • Jespersen T & al.
  • Nutr Metab Cardiovasc Dis
  • 21 Aug 2018

  • curated by Yael Waknine
  • Clinical Essentials
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Takeaway

  • Consuming up to 1 glass of wine daily is associated with lower prevalence of cardiovascular disease (CVD) in persons with chronic kidney disease (CKD) as well as the general US population.

Why this matters

  • Results also suggest that light wine consumption is tied to reduced odds of CKD.

Study design

  • Cross-sectional logistic regression analysis of 2003-2006 data from the National Health and Nutrition Examination Survey (NHANES) for 5852 persons aged ≥21 years; 18% had CKD.
  • Comparison involved light drinkers (
  • Incident CKD defined as urinary albumin/creatinine ratio (UACR) ≥30 mg/g or estimated glomerular filtration rate (eGFR, in mL/minute/1.73 m2)
  • CVD included angina, myocardial infarction, or stroke.
  • Funding: NIH/CRR Colorado CTSI.  

Key results

  • In unadjusted analysis, CKD prevalence was lower among light drinkers vs teetotalers (13.4% vs 19.7%; OR=0.63; P<.0001>
  • The association persisted in multivariate analysis adjusting for demographics and CVD risk factors with CKD defined by UACR (6.2% vs 11.5%; aOR=0.62; P=.006), but not eGFR (P=.87).
  • Light wine consumption was also associated with lower CVD rates among individuals with CKD (aOR=0.71; P=.02) and without (aOR=0.60; P=.001).

Limitations

  • Self-reported consumption; quantity not captured.
  • Cross-sectional design cannot prove causation.
  • Overall CVD proportion not given.

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