- Preoperatively measured donor kidney volume is a strong predictor of estimated glomerular filtration rate (eGFR) in recipients after living donor kidney transplantation (LDKT).
Why this matters
- Previous studies of smaller patient cohorts examining the effect of kidney allograft size have revealed conflicting results.
- Multivariable analysis showed donor kidney volume was significantly associated with eGFR (P<.001>
- Every 10-cc increase in donor kidney volume was linked to a rise in recipient eGFR at 1 month (1.68 mL/minute/1.73 m2), 3 months (1.25 mL/minute/1.73 m2), and 6 months (0.97 mL/minute/1.73 m2).
- Researchers studied CT-derived donor kidney volumes and recipient outcomes for 438 LDKTs.
- Mean donor kidney volume was 157.3 (±32.3) cc; mean weight was 186.7 (±48.7) g.
- Funding: None disclosed.
- The study was retrospective and single-center, with a small sample size.
- Prospective studies are needed to assess how well donor kidney volume predicts long-term eGFR.