Live donor kidney volume predicts transplant outcomes

  • World J Urol
  • 6 Dec 2018

  • curated by Craig Hicks
  • Clinical Essentials
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Takeaway

  • Preoperatively measured donor kidney volume is a strong predictor of estimated glomerular filtration rate (eGFR) in recipients after living donor kidney transplantation (LDKT).

Why this matters

  • Previous studies of smaller patient cohorts examining the effect of kidney allograft size have revealed conflicting results.

Key results

  • Multivariable analysis showed donor kidney volume was significantly associated with eGFR (P<.001>
  • Every 10-cc increase in donor kidney volume was linked to a rise in recipient eGFR at 1 month (1.68 mL/minute/1.73 m2), 3 months (1.25 mL/minute/1.73 m2), and 6 months (0.97 mL/minute/1.73 m2).

Study design

  • Researchers studied CT-derived donor kidney volumes and recipient outcomes for 438 LDKTs.
  • Mean donor kidney volume was 157.3 (±32.3) cc; mean weight was 186.7 (±48.7) g.
  • Funding: None disclosed.

Limitations

  • The study was retrospective and single-center, with a small sample size.
  • Prospective studies are needed to assess how well donor kidney volume predicts long-term eGFR.

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