- Liver disease is a risk factor for new-onset Afib.
- Liver disease scores correlated with increasing Afib risk.
Why this matters
- The study authors call their finding “novel” and say that clinicians should consider screening for Afib in patients with liver disease, especially high severity scores.
- With increasing Model for End-Stage Liver Disease (MELD) score quartiles, Afib prevalence was:
- 3.7%, quartile 1-10;
- 6.4%, quartile 11-20;
- 16.7%, quartile 21-30; and
- 20.2%, quartile >30.
- Compared with MELD quartile 1-10, HRs for new-onset Afib for other quartiles:
- 2.73 (95% CI, 1.47-5.07) for quartile 11-20;
- 5.41 (95% CI, 2.77-10.55) for quartile 21-30; and
- 9.33 (95% CI, 3.93-22.14) for quartile >30.
- Stroke risk also increased with increasing MELD score (P<.001>
- Age, sleep apnea, reduced ejection fraction were among other factors tied to Afib risk.
- Retrospective study, data for 1727 patients with liver disease evaluated for transplantation during 2006-2015; median follow-up, 1.04 years (interquartile range, 2 months to 3 years).
- Endpoint: effect of increasing MELD score on Afib risk.
- Funding: NIH.
- Single-center, retrospective, very specific patient population under consideration for transplantation.