Liver disease predicts Afib

  • J Am Heart Assoc

  • curated by Emily Willingham, PhD
  • Clinical Essentials
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • Liver disease is a risk factor for new-onset Afib.
  • Liver disease scores correlated with increasing Afib risk.

Why this matters

  • The study authors call their finding “novel” and say that clinicians should consider screening for Afib in patients with liver disease, especially high severity scores.

Key results

  • With increasing Model for End-Stage Liver Disease (MELD) score quartiles, Afib prevalence was:
    • 3.7%, quartile 1-10;
    • 6.4%, quartile 11-20;
    • 16.7%, quartile 21-30; and
    • 20.2%, quartile >30.
  • Compared with MELD quartile 1-10, HRs for new-onset Afib for other quartiles:
    • 2.73 (95% CI, 1.47-5.07) for quartile 11-20;
    • 5.41 (95% CI, 2.77-10.55) for quartile 21-30; and
    • 9.33 (95% CI, 3.93-22.14) for quartile >30.
  • Stroke risk also increased with increasing MELD score (P<.001>
  • Age, sleep apnea, reduced ejection fraction were among other factors tied to Afib risk.

Study design

  • Retrospective study, data for 1727 patients with liver disease evaluated for transplantation during 2006-2015; median follow-up, 1.04 years (interquartile range, 2 months to 3 years).
  • Endpoint: effect of increasing MELD score on Afib risk.
  • Funding: NIH.

Limitations

  • Single-center, retrospective, very specific patient population under consideration for transplantation.

Please confirm your acceptance

To gain full access to GPnotebook please confirm:

By submitting here you confirm that you have accepted Terms of Use and Privacy Policy of GPnotebook.

Submit