- Patients with multinodular (≥3 nodules) hepatocellular carcinoma (HCC) and cirrhosis undergoing liver resection had similar 30-day postoperative mortality and morbidity as patients without multinodular disease.
- Factors associated with worse outcomes included greater tumor numbers, tumor diameter, and microvascular invasion.
Why this matters
- Liver resection in patients with multinodular HCC with cirrhosis is controversial because of the potential for surgical complications.
- The results could assist with patient selection for resection.
- Retrospective multicenter analysis (n=1066; 160 [15%] with multinodular HCC).
- Funding: National Natural Science Foundation of China; Shanghai Pujiang Program.
- Postoperative 30-day results, nonmultinodular vs multinodular:
- Mortality: 1.8% vs 1.9% (P=.923).
- Major morbidity: 7.1% vs 7.5% (P=.843).
- Over the course of 60.1 months follow-up, multinodular vs nonmultinodular:
- 5-year OS: 34.6% vs 58.2% (P<.001>
- 5-year recurrence-free survival (RFS): 24.7% vs 44.5% (P<.001>
- Median OS: 46.0 months vs 78.4 months (P<.001>
- Median RFS: 11.1 months vs 29.6 months (P<.001>
- OS: HR, 1.686 (P=.002).
- RFS: HR, 2.035 (P=.020).
- Retrospective analysis.