- Young men with high-grade localized prostate cancer who received front-line radical prostatectomy (RP) showed significant improvement in survival vs those who had external beam radiation therapy (EBRT).
Why this matters
- Guidelines recommend both surgery and radiation therapy as appropriate treatment options for high-grade prostate cancer.
- Prospective randomized studies are, however, needed to confirm survival benefit of RP over EBRT.
- Study of 2228 patients with high-grade (Gleason score 8-10) localized prostate cancer aged
- Funding: None disclosed.
- Median follow-up was 43 months in patients who underwent RP (n=1459) and 44 months in those who received EBRT±brachytherapy (n=769).
- Patients undergoing RP showed lower estimated 7-year cancer-specific mortality (CSM; 8.2% vs 12.1%; P<.001 and overall mortality vs p>
- After adjusting for age, biopsy Gleason score, T stage, and PSA, initial RP vs EBRT significantly improved:
- CSM (HR, 0.37; P=.005) and
- overall mortality (HR, 0.41; P=.001).
- Retrospective design.