Low adiponectin tied to breast cancer risk in Asians, not whites

  • Yu Z & al.
  • Medicine (Baltimore)

  • curated by Miriam Davis, PhD
  • Univadis Clinical Summaries
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Takeaway

  • A meta-analysis finds that low serum levels of the protein hormone adiponectin may be associated with higher likelihood of breast cancer (BCa), but a subgroup analysis finds that this inverse association is driven by Asian but not white women.

Why this matters

  • With further study, low adiponectin might be a useful biomarker for BCa in Asian women.

Study design

  • Meta-analysis by Chinese researchers of 27 case-control studies (n≥1000) after search of PubMed, EMBASE, Wanfang database, and the China National Knowledge Infrastructure.
  • Funding: No external funds.

Key results

  • Low serum adiponectin levels were more likely in patients with BCa than control patients (mean difference [MD], −0.29; P<.001 i>2=97%), indicative of an inverse association.
    • In ethnic subgroup analysis, the inverse association was driven by Asian (−2.19; P<.001 but not caucasian p=".12)" women. other ethnicities were studied.>
    • In further subgroup analysis stratified by menopausal status, lower adiponectin levels were more likely in patients with BCa than healthy control patients who were premenopausal (MD, −0.74; P=.01; I2=41%) and postmenopausal (MD, −1.62: P=.04; I2=91%), but only in Asians (MD, −0.85 [P=.01]; and MD, −2.17 [P=.03], respectively), not Caucasians (P=.80; P=.60, respectively).
  • Serum adiponectin was not associated with BCa lymph node metastasis (P=.36).

Limitations

  • Some measures had high heterogeneity.
  • Small sample sizes.
  • Case-control designs.

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