Low fasting blood glucose ups CVD risk in absence of DM or cardiovascular disease

  • BMJ Open

  • International Clinical Digest
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Takeaway

  • In people without diabetes mellitus (DM) or cardiovascular disease (CVD), a low fasting blood glucose (

Why this matters

  • Results of this meta-analysis of prospective studies suggest the need for heightened vigilance and preventive measures in patients with low values. 

Key results

  • Compared with normal fasting blood glucose, fasting values
    • All-cause mortality: 1.56 (1.09-2.23),
    • Total stroke: 1.08 (1.03-1.13),
    • Ischemic stroke: 1.06 (1.01-1.10), and
    • Major cardiovascular events: 1.05 (1.03-1.07).
  • No increased risk for hemorrhagic stroke.
  • Fasting blood glucose
  • Study heterogeneity was high: I2, 67%-77%.

Study design

  • Systematic review, meta-analysis of 11 articles covering 129 prospective studies that included 2,674,882 people without diabetes or CVD (mean age, 48 years; 32% women; average follow-up, 14.3 [range, 1-20] years).
  • Funding: Ministry of Science and Technology, Taiwan.

Limitations

  • Reasons for low blood glucose not known.
  • Variable definitions of low fasting blood glucose among studies.