- Low levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with early onset of coronary atherosclerosis in symptomatic patients.
Why this matters
- The effect of EPA and DHA on vascular calcification in humans is unclear.
- This study improves our understanding of the pathophysiology of omega-3 fatty acids, which potentially explains their beneficial effects.
- Prospective analysis of symptomatic patients with low to intermediate pre-test-likelihood who presented with atypical angina (n=71).
- Patient characteristics: mean age, 62 years; mean BMI, 28 kg/m2; mean number of cardiovascular risk factors, 2.4.
- The presence of coronary artery calcification (CAC) above 75th percentile was calculated (defined as association of EPA and DHA with early-onset coronary atherosclerosis).
- Funding: None disclosed.
- The groups with 75th (n=20) Agatston-Score (AS) percentile showed a significant difference in CAC measurements (including CAC volume, mass, and AS; all P<.001>
- In the group >75th vs
- EPA (0.77% vs 0.93%; P=.045);
- DHA (4.90% vs 5.50%; P=.038); and
- Omega-3 Index (5.73% vs 6.22%; P=.034).
- Small sample size.
- Intake of EPA- and DPA-rich sources not assessed.