Low-normal thyroid function tied to anemia risk

  • Gu Y & al.
  • J Clin Endocrinol Metab
  • 30 Jul 2019

  • International Clinical Digest
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Takeaway

  • Low-normal levels of free triiodothyronine (FT3) and free thyroxine (FT4) are associated with incidence of anemia and annual changes in hemoglobin.

Why this matters

  • This is the first study to directly evaluate the effects of thyroid hormone levels on anemia risk in a euthyroid population.

Key results

  • The incidence rate of anemia was 14/1000 person-years during follow-up.
  • Levels of FT3 and FT4 were inversely associated with anemia incidence (HR, 0.70 [P<.01 hr per pmol change respectively style="list-style-type:circle;">
  • Thyroid-stimulating hormone (TSH) levels were not significantly associated (HR, 1.19; P=.14).
  • Levels of FT3 and FT4 were positively associated with annual changes in hemoglobin (standard regression coefficients: 0.056 [P<.0001 and respectively>

    Study design

    • 12,310 participants with euthyroid status were analyzed for thyroid hormone levels and incidence of anemia during approximately 5 years of follow-up (mean, 3.1 years).
    • Funding: National Natural Science Foundation of China.

    Limitations

    • Observational study design.
    • Relationship between thyroid status and iodine intake not analyzed.