- Low prognostic nutritional index (PNI) is associated with reduced OS in patients with nasopharyngeal carcinoma (NPC), according to a retrospective study.
Why this matters
- Identification of prognostic factors can help stratify patient treatment selection.
- Patients with low PNI (≤45.45) had a lower 5-year OS rate than patients with high PNI (>45.45; 52.9% vs 79.0%; P=.03).
- Patients with a low albumin-globulin ratio (AGR; ≤1.19) had a lower 5-year OS rate than patients with a high AGR (>1.19; 57.7% vs 82.0%; P=.04).
- Age >50 years (HR, 2.70; 95% CI, 1.091-6.719) and low PNI (HR, 2.44; 95% CI, 1.009-5.940) were associated with reduced OS in multivariate analysis.
- 5-year OS in combined analysis (P=.004 for low vs high-risk):
- High risk (low PNI and AGR): 42.9%.
- Intermediate risk (low PNI/high AGR, high PNI/low AGR): 80.3%.
- Low risk (high PNI and AGR): 80.9%.
- 95 patients with nonmetastatic NPC were included.
- Funding: None disclosed.
- Retrospective study.
- Small patient sample size.