Low PNI predicts poor survival in nasopharynx cancer

  • Gundog M & al.
  • Eur Arch Otorhinolaryngol
  • 10 Aug 2019

  • curated by Brian Richardson, PhD
  • Univadis Clinical Summaries
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • Low prognostic nutritional index (PNI) is associated with reduced OS in patients with nasopharyngeal carcinoma (NPC), according to a retrospective study.

Why this matters

  • Identification of prognostic factors can help stratify patient treatment selection.

Key results

  • Patients with low PNI (≤45.45) had a lower 5-year OS rate than patients with high PNI (>45.45; 52.9% vs 79.0%; P=.03).
  • Patients with a low albumin-globulin ratio (AGR; ≤1.19) had a lower 5-year OS rate than patients with a high AGR (>1.19; 57.7% vs 82.0%; P=.04).
  • Age >50 years (HR, 2.70; 95% CI, 1.091-6.719) and low PNI (HR, 2.44; 95% CI, 1.009-5.940) were associated with reduced OS in multivariate analysis.
  • 5-year OS in combined analysis (P=.004 for low vs high-risk):
    • High risk (low PNI and AGR): 42.9%.
    • Intermediate risk (low PNI/high AGR, high PNI/low AGR): 80.3%.
    • Low risk (high PNI and AGR): 80.9%.

Study design

  • 95 patients with nonmetastatic NPC were included.
  • Funding: None disclosed.

Limitations

  • Retrospective study.
  • Small patient sample size.