Low total, free T3 levels tied to IR in nondiabetic adults

  • Sci Rep

  • curated by Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • Low levels of the thyroid hormones total and free triiodothyronine (TT3 and FT3) are associated with insulin resistance (IR) in nondiabetic individuals.

Why this matters

  • This large, population-based study addresses the controversial relationship between thyroid hormone levels and IR.

Key results

  • Race, liver function, obesity, hypertension, dyslipidemia, smoking, physical activity, vigorous recreational activity, 2-hour glucose, HbA1c, high-density lipoprotein, triglyceride, vitamin D, and C-reactive protein were associated with IR in univariate analysis.
  • Low TT3 and low FT3 were associated with IR in analysis adjusted for the above factors (coefficient, −0.486 [95% CI, −0.936 to −0.036] and −1.151 [95% CI, −1.952 to −0.350], respectively).

Study design

  • 1560 nondiabetic participants from the 2007-2008 US National Health and Nutrition Examination Survey (NHANES) were analyzed for factors associated with IR by homeostatic model assessment.
  • Funding: Ministry of Science and Technology, Taiwan.

Limitations

  • Retrospective analysis of large database that lacks some treatment and outcome information.

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