Findings from a new study suggest that older people who receive the influenza vaccine could have a significantly lower risk of acute kidney injury (AKI).
AKI following influenza infection is not uncommon in the older population and this latest research set out to examine whether vaccination against influenza is associated with a reduced risk of AKI.
Using Taiwan's National Health Insurance Research Database, researchers examined data on 13,270 patients aged at least 65 years who were hospitalised for AKI between 2000 and 2013, and 13,270 matched controls.
They found that while influenza infection was associated with an increased risk of AKI, the risk of AKI was 37 per cent lower among older people who received vaccination against influenza. The inverse association of influenza vaccination with AKI was consistent in subgroups defined according to age, sex, baseline comorbidities, prior vaccination status, and influenza season.
“Further prospective studies are needed to define the causality of this association and to determine whether a protective effect of influenza vaccination against acute renal insult is biologically plausible,” the authors concluded.
The findings are published in the European Journal of Internal Medicine.