- Patients with lung cancer are significantly more likely to develop an abdominal aortic aneurysm (AAA) than those without lung cancer.
Why this matters
- With the known association between smoking and AAAs, these data support extending low-dose chest CT to include the abdomen as a simultaneous screen for both diseases in high-risk patients.
- 814 patients with primary lung cancer and 200 people without cancer (control group).
- Funding: None disclosed.
- Prevalence of AAA was significantly higher in patients with lung cancer (11.1%) compared with the control group (2%; P=.0001).
- 60% of AAAs were 5.5 cm (without accounting for repaired aneurysms).
- 88.7% of patients with lung cancer were current or former smokers.
- Having a smoking history was associated with a significantly higher incidence of AAA (11.9% vs 2.2% without; P=.0047).
- Prevalence of AAA was 12.8% in patients with stage I cancer, 6.8% with stage II, 7.5% with stage III, and 5.6% with stage IV.
- Independent risk factors (ORs) for AAA:
- Male sex: 3.70 (P<.001>
- Increasing age: 1.07 per year (P<.001>
- Smoking: 1.01 per pack-year (P=.004).
- Hypertension: 2.30 (P=.020).
- Single-center, retrospective study.