Lung cancer: prediagnostic weight loss more prognostic than BMI

  • Lung Cancer

  • curated by Kelli Whitlock Burton
  • Univadis Clinical Summaries
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Takeaway

  • Prediagnosis weight loss is a strong indicator of survival in patients with lung cancer.

Why this matters

  • Although 1-year OS was higher in patients who were obese or overweight, BMI was only associated with survival in patients with stage IIIB disease.

Study design

  • BMI data on 6595 patients with lung cancer from the French KBP-2010-CPHG cohort.
  • Funding: AstraZeneca; BMS; others.

Key results

  • 12% of patients were obese, 28% overweight, 45% normal weight, and 15% underweight.
  • Prediagnosis weight loss reported in 35% of obese patients, 43% of overweight patients, 57% of normal weight patients, and 75% of underweight patients.
  • Mean 1-year OS was lower in underweight patients than in patients with normal weight (32% vs 43%), and higher in overweight and obese patients (50% and 53%, respectively).
  • Mortality risk increased with increasing prediagnosis weight loss (
  • BMI was only an independent prognostic factor of OS in patients with stage IIIB cancer (HR, 0.75; 95% CI, 0.75-0.97).

Limitations

  • No data on comorbidities or causes of death.

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