- Patients with lung cancer who quit smoking ≥15 years before their diagnosis and those who were ≤5 years younger than the recommended age cutoff, but otherwise met US Preventive Services Task Force (USPSTF) lung cancer screening criteria, had a similar mortality risk as people who meet all USPSTF criteria.
Why this matters
- These findings, along with earlier research suggesting that nearly two-thirds of patients with lung cancer do not meet USPSTF screening criteria, suggest a guidelines revision could improve patient outcomes.
- A similar recent study focused on African Americans.
- Prospective, observational cohort, multicenter study.
- 8739 patients diagnosed with lung cancer between 1997 and 2017 from hospital and community cohorts.
- Median follow-up, 6.5 years.
- Funding: NIH; Mayo Clinic Foundation.
- 6627 of the overall cohort met USPSTF criteria.
- 5-year OS was 27% in smokers who quit within the last 30 years, 22% in those
- 5-year OS was not significantly different between long-term quitters and the USPSTF group (hospital cohort HR, 1.02 [P=.72]; community cohort HR, 0.97 [P=.82]) or those
- Results were similar after propensity matching.
- Unmeasured confounders could have influenced OS.