- Magnesium intake was inversely associated with type 2 diabetes (T2D) and total stroke in a dose-dependent manner.
Why this matters
- Findings support the guidelines to address the role of magnesium intake in early prevention strategies to prevent T2D and stroke.
- 41 prospective studies met eligibility criteria after a search across PubMed, Embase, and other databases.
- Funding: National Natural Science Foundation of China and others.
- Higher magnesium intake vs lower intake was associated with significant reduction in the risk of:
- T2D (relative risk [RR], 0.78; 95% CI, 0.75-0.81);
- stroke (RR, 0.89; 95% CI, 0.83-0.94) and;
- ischaemic stroke (RR, 0.88; 95% CI, 0.81-0.95; P<.001 for all>
- T2D and stroke risk was lower after adjustment for cereal fibre (RR, 0.79; 95% CI, 0.73-0.85; P<.001 and calcium ci p=".040)," respectively.>
- In subgroup analyses, the risk for total stroke and ischaemic stroke, respectively was reduced in:
- RR, 0.91; 95% CI, 0.83-0.99; and
- RR, 0.89; 95% CI, 0.79-1.00.
- those with body mass index ≥25 mg/m2:
- RR, 0.89; 95% CI, 0.82-0.96; and
- RR, 0.88; 95% CI, 0.81-0.96.
- those with ≥12-year follow-up:
- RR, 0.89; 95% CI, 0.83-0.95; and
- RR, 0.88; 95% CI, 0.81-0.95.
- Non-inclusion of randomised controlled trials to prove the causality.