Magnesium intake inversely associated with T2D and stroke

  • Zhao B & al.
  • BMJ Open
  • 19 Mar 2020

  • curated by Sarfaroj Khan
  • UK Clinical Digest
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • Magnesium intake was inversely associated with type 2 diabetes (T2D) and total stroke in a dose-dependent manner.

Why this matters

  • Findings support the guidelines to address the role of magnesium intake in early prevention strategies to prevent T2D and stroke.

Study design

  • 41 prospective studies met eligibility criteria after a search across PubMed, Embase, and other databases.
  • Funding: National Natural Science Foundation of China and others.

Key results

  • Higher magnesium intake vs lower intake was associated with significant reduction in the risk of:
    • T2D (relative risk [RR], 0.78; 95% CI, 0.75-0.81);
    • stroke (RR, 0.89; 95% CI, 0.83-0.94) and;
    • ischaemic stroke (RR, 0.88; 95% CI, 0.81-0.95; P<.001 for all>
  •  T2D and stroke risk was lower after adjustment for cereal fibre (RR, 0.79; 95% CI, 0.73-0.85; P<.001 and calcium ci p=".040)," respectively.>
  • In subgroup analyses, the risk for total stroke and ischaemic stroke, respectively was reduced in:
    • women:
      • RR, 0.91; 95% CI, 0.83-0.99; and
      • RR, 0.89; 95% CI, 0.79-1.00.
    • those with body mass index ≥25 mg/m2:
      • RR, 0.89; 95% CI, 0.82-0.96; and
      • RR, 0.88; 95% CI, 0.81-0.96.
    • those with ≥12-year follow-up:
      • RR, 0.89; 95% CI, 0.83-0.95; and
      • RR, 0.88; 95% CI, 0.81-0.95.

Limitations

  • Non-inclusion of randomised controlled trials to prove the causality.