Male breast cancer: no link between histologic grade, OS

Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

 

  • Unlike female breast cancer, higher histological grade of male breast cancer is not associated with OS.
  • Other histological features are associated with OS, similar to female breast cancer.

Why this matters

 

 

  • Findings suggest more research is needed to enable risk stratification of male patients, which affects treatment decisions.

Study design

 

 

  • 1483 male breast cancer specimens were collected from 1990 to 2010 through the European Organisation for Research and Treatment of Cancer (EORTC).
  • Central pathology review focused on histological subtype, grade, mitotic activity index (MAI), presence of a fibrotic focus, and density of tumor-infiltrating lymphocytes (TILs).
  • Histological characteristics were correlated with clinical outcome.
  • Funding: Breast Cancer Research Foundation, the Dutch Pink Ribbon, the European Breast Cancer Council, and Susan G. Komen for the Cure.

Key results

 

 

  • Overall histological grade was not significantly correlated with OS (P=.129).
  • MAI (P=.023), the presence of fibrotic focus (P=.004), and low TIL density (P=.011) were, similar to female breast cancer, correlated with unfavorable OS.
  • There was no association between subtype and fibrotic focus.

Limitation

 

 

  • Treatments were not highly standardized, which could have confounded findings.