Male breast cancer: no link between histologic grade, OS

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  • Unlike female breast cancer, higher histological grade of male breast cancer is not associated with OS.
  • Other histological features are associated with OS, similar to female breast cancer.
Why this matters
  • Findings suggest more research is needed to enable risk stratification of male patients, which affects treatment decisions.
Study design
  • 1483 male breast cancer specimens were collected from 1990 to 2010 through the European Organisation for Research and Treatment of Cancer (EORTC).
  • Central pathology review focused on histological subtype, grade, mitotic activity index (MAI), presence of a fibrotic focus, and density of tumor-infiltrating lymphocytes (TILs).
  • Histological characteristics were correlated with clinical outcome.
  • Funding: Breast C...