- Maternal cardiovascular dysfunction may play a role in fetal growth restriction (FGR) and preeclampsia (PE).
Why this matters
- Early-onset PE and FGR are associated with abnormal maternal cardiac function (low cardiac output and high vascular resistance).
- These authors suggest 2 pathways to PE depending on the presence or absence of FGR.
- They suggest that maternal cardiovascular dysfunction precedes FGR and PE rather than being initiated by placental maldevelopment, the current theory.
- Assessment of maternal cardiovascular function may be an important adjunctive modality in determining fetal health and in surveillance of pregnancies at risk for PE and FGR.
- There is a relationship between maternal cardiovascular function and uterine and fetal Doppler indices.
- Mean uterine pulsatility index was higher in FGR (1.37) and PE+FGR (1.63) but not PE alone (0.92) when compared with controls (0.8) (P<.001>
- Prospective cohort study between 2015 and 2017.
- Women were stratified into 4 groups: FGR alone (n=17), PE alone (n=13), FGR+PE (n=15), and controls (n=62).
- All women underwent serial ultrasound scans for fetal biometry and Doppler velocimetry.
- Funding: None.
- Small numbers in study.