Maternal urine bisphenol linked to pediatric neurodevelopmental scores at age 2 years

  • Jiang Y & al.
  • J Hazard Mater
  • 28 Nov 2019

  • curated by Elisabeth Aron, MD, MPH, FACOG
  • Clinical Essentials
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Takeaway

  • Maternal urine bisphenol levels during pregnancy are tied to decreased psychomotor development scores in offspring at age 2 years.

Why this matters

  • Bisphenols (BPA, BPS, and BPF) are endocrine disruptors.

Key results

  • Rates of bisphenol detection in maternal urine samples (with fair-poor reproducibility):
    • BPA: 76.3%-78.9%;
    • BPS: 81.8%-88.2%; and
    • BPF: 98.2%-98.5%.
  • BPS:
    • Psychomotor development index (PDI) scores in children at age 2 years decreased across quartiles: −5.52 (95% CI, −10.06 to −0.99; fourth vs first quartiles). 
    • After sex stratification, associations significant in males only: −7.61 (95% CI, −13.99 to −1.24).
  • BPA:
    • Second-trimester urine levels were associated with lower Mental Development Index scores: −2.87 (95% CI, −4.98 to −0.75).
    • No association seen with PDI scores.
  • BPF:
    • No significant associations.

Study design

  • Prospective longitudinal cohort study.
  • Pregnant women with prenatal care and their offspring were included (456 mother-child pairs).
  • Maternal urine samples collected during each trimester.
  • Pediatric neurodevelopment assessment performed at age 23-26 months.
  • Funding: National Natural Science Foundation of China; Health Commission of Hubei Province; others.

Limitations

  • Rates of bisphenol exposure differ among countries.
  • Postpartum exposure to bisphenols not evaluated.
  • Risk for residual confounding.
  • Maternal urine levels used as proxy for fetal exposure.