- Maternal urine bisphenol levels during pregnancy are tied to decreased psychomotor development scores in offspring at age 2 years.
Why this matters
- Bisphenols (BPA, BPS, and BPF) are endocrine disruptors.
- Rates of bisphenol detection in maternal urine samples (with fair-poor reproducibility):
- BPA: 76.3%-78.9%;
- BPS: 81.8%-88.2%; and
- BPF: 98.2%-98.5%.
- Psychomotor development index (PDI) scores in children at age 2 years decreased across quartiles: −5.52 (95% CI, −10.06 to −0.99; fourth vs first quartiles).
- After sex stratification, associations significant in males only: −7.61 (95% CI, −13.99 to −1.24).
- Second-trimester urine levels were associated with lower Mental Development Index scores: −2.87 (95% CI, −4.98 to −0.75).
- No association seen with PDI scores.
- No significant associations.
- Prospective longitudinal cohort study.
- Pregnant women with prenatal care and their offspring were included (456 mother-child pairs).
- Maternal urine samples collected during each trimester.
- Pediatric neurodevelopment assessment performed at age 23-26 months.
- Funding: National Natural Science Foundation of China; Health Commission of Hubei Province; others.
- Rates of bisphenol exposure differ among countries.
- Postpartum exposure to bisphenols not evaluated.
- Risk for residual confounding.
- Maternal urine levels used as proxy for fetal exposure.