- Systematic review found high prevalence (29%-66%) of nonadherence in adults taking antiepileptic drugs (AEDs).
- Authors advise regular assessment of adherence for patients taking AEDs.
- AED nonadherence has been associated with poor QoL, suboptimal clinical outcome, and increased mortality.
- First systematic review to explore barriers to medication adherence among adults with epilepsy.
- Systematic review of articles from MEDLINE, CINANL, PsycINFO, EMBASE, and Cochrane databases for articles on epilepsy including patients >18 y prescribed AEDs that included adherence measurements.
- 8 studies included.
- Funding: None.
- High prevalence of nonadherence (29%-66%).
- AED nonadherence associated with beliefs about medications (perception of true need and sensitivity to adverse effects), depression and anxiety, poor self-administration of medication (forgetfulness and reports of not having time), uncontrolled recent seizures, medication complexity (dosing times, instructions), poor physician-patient relationship, and lack of social support.
- Adherence seemed to improve with age.
- Nonadherence had negative effect on QoL via poor seizure control.
- Heterogeneity of studies.