- High adherence to the Mediterranean diet was associated with a reduced risk for bladder cancer.
- Association was independent of cancer subtype, sex, fat intake.
Why this matters
- Bladder Cancer Epidemiology and Nutritional Determinants (BLEND) is the largest pooled cohort study to investigate associations between adherence to the Mediterranean diet and risk for bladder cancer.
- Study of dietary data from the BLEND including 3639 incident bladder cancer cases and 642,583 participants without bladder cancer across 13 cohort studies.
- Funding: None.
- After adjustment for total energy intake, smoking status, and sex compared with low adherence to Mediterranean diet, risk for bladder cancer was significantly lower with:
- high adherence (aHR, 0.85; 95% CI, 0.77-0.93) and
- medium adherence (aHR, 0.91; 95% CI, 0.85-0.99).
- An inverse linear association was observed between Mediterranean diet and risk for bladder cancer (aHR for a 1-unit increase in adherence, 0.96; 95% CI, 0.94-0.98).
- The association remained significant for:
- muscle-invasive and non-muscle-invasive disease,
- men and women, and
- after excluding either fats or alcohol from diet score.
- Information on other risk factors was limited.