Melanoma: tumor thickness tied to recurrence, distant metastasis

  • Cho SI & al.
  • PLoS One
  • 1 Jan 2019

  • curated by Brian Richardson, PhD
  • Univadis Clinical Summaries
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Takeaway

  • A retrospective study suggests that tumor thickness and mitotic number are associated with outcomes following surgical treatment in patients with malignant melanoma.

Why this matters

  • Better understanding of risk factors can help guide patient management.

Key results

  • 22.7% of patients developed distant metastasis and 9.41% developed local recurrence.
  • Tumor thickness (aHR, 6.139; P=.001) and increased mitotic number (aHR, 4.483; P=.023 for 2-6 vs 0-1/mm2; aHR, 10.316; P<.001 for>6 vs 0-1/mm2) were associated with increased risk of distant metastasis in multivariate analysis.
  • Tumor thickness (aHR, 8.461; P=.001) was associated with increased risk of local recurrence in multivariate analysis.

Study design

  • 202 patients with malignant melanoma who underwent surgical excision were analyzed for risk factors for distant metastasis and local recurrence.
  • Funding: None.

Limitations

  • Retrospective study.

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