Higher intake of dietary carbohydrate may increase the risk for colorectal cancer in men, a new meta-analysis has revealed. The findings were published in Bioscience Reports.
Cases of colorectal cancer rising at a fast pace making it a global concern. Developing countries were reported to be at an 18% higher risk compared with the other countries. Although insulin resistance is known to be an etiological factor, the role of dietary carbohydrates remains uncertain.
Researchers screened PubMed, EMBASE, Web of Science, and MEDLINE databases up to September 2016. A total of 17 articles (8 case-control design and 9 prospective design) were selected which included 14,402 patients with colorectal cancer and 846,004 participants.
The authors found a significant association between high carbohydrate intake and colorectal cancer in men (relative risk [RR]=1.23), but not in women. The Pooled RR for colorectal cancer, colon cancer, and rectum cancer with higher dietary intake of carbohydrates were 1.08 (Pheterogeneity<.001), 1.09, and 1.17, respectively.
The authors suggest the need for further trials from Asia and Europe to confirm the association.