Merkel cell carcinoma: study identifies predictors of positive SLN

  • J Am Acad Dermatol

  • curated by Brian Richardson, PhD
  • Univadis Clinical Summaries
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Takeaway

  • Trunk location, presence of tumor-infiltrating lymphocytes (TILs), and lymphovascular invasion (LVI) are associated with positive results on sentinel lymph node (SLN) biopsy in patients with Merkel cell carcinoma (MCC).

Why this matters

  • Few studies have examined which tumor characteristics are associated with SLN positivity and survival in patients with MCC.

Key results

  • 30.8% of patients had a positive SLN biopsy.
  • Trunk location (OR, 1.98; P=.004), presence of TILs (OR, 1.58; P=.04), and LVI (OR, 3.45; P<.001 were associated with sln in multivariate analysis.>
  • Age ≥75 years (HR, 2.55; P=.003), male sex (HR, 1.78; P=.022), immunosuppression (HR, 3.51; P=.001), and SLN positivity (HR, 3.15; P<.001 were associated with reduced os in multivariate analysis.>

Study design

  • 1174 patients with MCC who underwent SLNB from the National Cancer Database were included.
  • Funding: None disclosed.

Limitations

  • Retrospective analysis of a large database.
  • No analysis of disease-specific survival.

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