- Trunk location, presence of tumor-infiltrating lymphocytes (TILs), and lymphovascular invasion (LVI) are associated with positive results on sentinel lymph node (SLN) biopsy in patients with Merkel cell carcinoma (MCC).
Why this matters
- Few studies have examined which tumor characteristics are associated with SLN positivity and survival in patients with MCC.
- 30.8% of patients had a positive SLN biopsy.
- Trunk location (OR, 1.98; P=.004), presence of TILs (OR, 1.58; P=.04), and LVI (OR, 3.45; P<.001 were associated with sln in multivariate analysis.>
- Age ≥75 years (HR, 2.55; P=.003), male sex (HR, 1.78; P=.022), immunosuppression (HR, 3.51; P=.001), and SLN positivity (HR, 3.15; P<.001 were associated with reduced os in multivariate analysis.>
- 1174 patients with MCC who underwent SLNB from the National Cancer Database were included.
- Funding: None disclosed.
- Retrospective analysis of a large database.
- No analysis of disease-specific survival.