- A systematic review and meta-analysis finds that 26% of adult patients with atopic dermatitis (AD) first developed the disease as an adult.
Why this matters
- This systematic review and meta-analysis indicated that AD is not only a disease of childhood, which was unclear in prior studies.
- 17/25 included studies reported age of AD onset past 16 years.
- 26.1% of adult patients with AD reported adult-onset disease.
- The highest proportion of adult-onset AD was observed in the United States (53.0%), with lower proportions in Europe (24.0%), Asia (21.4%), and other regions (24.3%).
- Child-onset AD was consistently linked with higher proportions of facial dermatitis, conjunctivitis/eyelid dermatitis, cheilitis, pruritus after sweating, xeroderma or xerosis, hand and foot dermatitis, nipple dermatitis, and Dennie-Morgan line.
- Adult-onset AD was consistently linked with higher proportion of lesions on feet and white dermatographism.
- 25 studies including age of AD onset were subjected to meta-analysis.
- Funding: Agency for Healthcare Research and Quality; Dermatology Foundation.
- Many studies did not report on the differing characteristics between adult- and childhood-onset AD.