Meta-analysis: atopic dermatitis may increase CVD risk

  • J Allergy Clin Immunol

  • curated by Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • A meta-analysis suggests that atopic dermatitis (AD) is associated with increased risk for cardiovascular disease (CVD), although associations were only significant in cohort studies.

Why this matters

  • Meta-analysis adds further evidence for a link between AD and cardiovascular disease and suggests that AD severity is an important factor.

Key results

  • In cohort studies, AD was associated with increased risk for myocardial infraction (4 studies; relative risk [RR], 1.12; 95% CI, 1.00-1.25), stroke (4 studies; RR, 1.10; 95% CI, 1.03-1.17), ischemic stroke (4 studies; RR, 1.17; 95% CI, 1.14-1.20), angina (2 studies; RR, 1.18; 95% CI, 1.13-1.24), and heart failure (2 studies; RR, 1.26; 95% CI, 1.05-1.51).
  • RRs for CVD increased with AD severity (mean RR increase, 1.15 between severity categories; 95% credibility interval [Crl], 1.09-1.21).
    • RR per unit increase in severity, 1.16 (95% Crl, 1.07-1.26) for angina, 1.20 (95% Crl, 1.06-1.36) for heart failure, 1.25 (95% Crl, 1.13-1.38) for cardiovascular death, and 1.14 (95% Crl, 1.05-1.23) for myocardial infraction.

Study design

  • 19 studies (8 cohort, 1 case-control, and 10 cross-sectional) matched eligibility criteria; 17 were included in the meta-analysis.
  • Funding: British Association of Dermatologists; NIH; Robert Wood Johnson Foundation and Dermatology Foundation; Wellcome Trust.

Limitations

  • Heterogeneity between studies.

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