Meta-analysis: atopic dermatitis tied to extracutaneous infections

  • Serrano L & al.
  • J Am Acad Dermatol
  • 21 Nov 2018

  • curated by Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • A systematic review and meta-analysis suggest that patients with atopic dermatitis (AD) have increased risk for extracutaneous infections.

Why this matters

  • The relationship between AD and risk for extracutaneous infections is controversial; this meta-analysis suggests that infection risk should be included in management planning of patients with AD.

Key results

  • In pooled meta-analysis, AD in children and adults was associated with increased risk for ear infection (3 studies; 26.6% vs 21.9%; OR, 1.29; P<.0001 strep throat studies vs or and urinary tract infection>
  • AD was not significantly associated with risk for pneumonia (5 studies; 8.8% vs 5.4%; OR, 1.72; P=.20).
  • Publication bias was not detected in studies included in the meta-analysis (Egger regression P≥.24; Begg rank correlation P≥.36).

Study design

  • 7 observational studies were subjected to meta-analysis to determine the relationship between AD and risk for extracutaneous infection.
  • Funding: Dermatology Foundation.

Limitations

  • Small collection of observational, mostly retrospective studies.
  • Only 1 study included analysis of AD severity.

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