- A systematic review and meta-analysis suggest that patients with atopic dermatitis (AD) have increased risk for extracutaneous infections.
Why this matters
- The relationship between AD and risk for extracutaneous infections is controversial; this meta-analysis suggests that infection risk should be included in management planning of patients with AD.
- In pooled meta-analysis, AD in children and adults was associated with increased risk for ear infection (3 studies; 26.6% vs 21.9%; OR, 1.29; P<.0001 strep throat studies vs or and urinary tract infection>
- AD was not significantly associated with risk for pneumonia (5 studies; 8.8% vs 5.4%; OR, 1.72; P=.20).
- Publication bias was not detected in studies included in the meta-analysis (Egger regression P≥.24; Begg rank correlation P≥.36).
- 7 observational studies were subjected to meta-analysis to determine the relationship between AD and risk for extracutaneous infection.
- Funding: Dermatology Foundation.
- Small collection of observational, mostly retrospective studies.
- Only 1 study included analysis of AD severity.