- A meta-analysis finds that high intake of sugar-sweetened beverages (SSB) and fruit juices, but not fruit, is associated with incident gout.
Why this matters
- Gout is problematic in its own right, but is also associated with development of hypertension, insulin resistance, and cardiovascular disease.
- Meta-analysis of 3 prospective cohorts (n=154,289; 1761 cases of gout), including the Nurses' Health Study and the National Runner's Health Study.
- Quality of evidence was evaluated by the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system.
- Funding: Canadian Institutes of Health Research; other.
- High vs low intake of fruit juice (risk ratio [RR], 1.77; 95% CI, 1.20-2.61; I2=0%; very low certainty) was associated with incident gout, as was high vs low SSB intake (RR, 2.08; 95% CI, 1.40-3.08; I2=0%; moderate certainty).
- High vs low fruit intake was not associated with incident gout (RR, 0.85; 95% CI, 0.63-1.14; I2=93%; very low certainty).
- High heterogeneity and very low certainty for the fruit intake finding; very low certainty for the fruit juice finding.
- Observational designs.