- A systematic review and meta-analysis suggest that high serum levels of adiponectin are associated with an increased mortality rate, which is partly modulated by natriuretic peptides.
Why this matters
- Serum adiponectin was thought to have a beneficial role in the treatment of cardiovascular disease, but recent studies and this meta-analysis suggest a surprising link between high adiponectin levels and mortality.
- High serum adiponectin was associated with increased all-cause mortality (HR, 1.24; P<.0001 and cardiovascular mortality>
- In studies adjusting for natriuretic peptides, the association between adiponectin and mortality was attenuated (HR, 1.13 [P=.0003] for all-cause mortality; HR, 1.15 [P=.001] for cardiovascular mortality).
- 55 studies including 61,676 subjects and 28 studies including 43,979 subjects reported associations between adiponectin and all-cause and cardiovascular mortality, respectively, and were subjected to meta-analysis.
- Funding: Italian Ministry of Health; Italian Ministry of University and Scientific Research; Società Italiana di Diabetologia-Fondazione Diabete Ricerca.
- Analysis assumed a linear association between adiponectin and morality.