- While the prevalence of comorbid depression is similarly high in irritable bowel syndrome (IBS) and IBD, the severity of depression and anxiety is greater in IBS.
Why this matters
- Comorbid depression and anxiety warrant evaluation and treatment regardless of disorder.
- Meta-analysis of 22 studies (n=1244 with IBS; n=1048 with IBD) that met eligibility criteria after search of PubMed, PsycINFO, Embase, Cochrane Library, Wan Fang, SinoMed, and Chinese National Knowledge Infrastructure.
- Funding: Beijing Municipal Administration; Beijing Municipal Science and Technology Commission.
- 72.7% of studies were judged to be "high quality" according to the Newcastle-Ottawa Scale.
- No difference was seen in prevalence of depression between IBD and IBS.
- The IBS group had depression of greater severity (pooled standardized mean difference [SMD], 0.18; P=.01) and anxiety of greater severity (pooled SMD, 0.31; P=.0006) than the IBD group.
- No reporting of actual prevalence rates.
- Heterogeneity across studies.
- Depression and anxiety based on self-reported scales that varied across studies.