- Rosacea is associated with increased risk for hypertension and dyslipidemia, according to a systematic review and meta-analysis.
Why this matters
- The association between rosacea and cardiometabolic disease is controversial.
- Rosacea vs no rosacea was associated with increased pooled risk ratios (RRs) for:
- Dyslipidemia: 1.32 (P=.002); and
- Hypertension: 1.20 (P=.001).
- Rosacea vs no rosacea was associated (standardized mean differences) with increased:
- Total cholesterol: 0.42 (P=.001);
- Low-density lipoprotein: 0.37 (P=.000);
- Triglycerides: 0.28 (P=.006);
- Systolic BP: 0.40 (P=.000);
- Diastolic BP: 0.50 (P=.002); and
- Fasting blood glucose: 0.24 (P=.026).
- Rosacea was not significantly associated (RRs) with:
- Ischemic heart disease: 0.89 (P=.575);
- Stroke: 0.94 (P=.705); or
- Diabetes: 1.15 (P=.216).
- Rosacea also was not significantly associated with levels of high-density lipoprotein (standardized mean difference, −0.01; P=.859).
- 13 studies (50,442 patients with rosacea) were included in the meta-analysis.
- Funding: National Natural Science Foundation of China.
- Heterogeneity among included studies.
- No subgroup analysis by rosacea subtype or severity.